(+)-Norfenfluramine, the principal hepatic metabolite of (+)-fenfluramine, acts as a selective agonist for the 5-HT2B receptor, exhibiting a potent K i of 11.2 nM. It significantly promotes the hydrolysis of inositol phosphates and heightens intracellular Ca2+ levels. This compound is valuable in the study of primary pulmonary hypertension and valvular heart disease.
Molecular Weight:
203.2
CAS Number:
[19036-73-8]
Formula:
C10H12F3N
Target:
5-HT Receptor
T72510
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