(R)-Afatinib ((R)-BIBW 2992), an isomer of Afatinib, is a potent, orally administered, irreversible inhibitor targeting the ErbB family (EGFR and HER2) with IC50 values of 0.5 nM for EGFR wt, 0.4 nM for EGFR L858R, 10 nM for EGFR L858R/T790M, and 14 nM for HER2, holding potential for research into esophageal squamous cell carcinoma (ESCC), non-small cell lung cancer (NSCLC), and gastric cancer [1].
Molecular Weight:
485.94
CAS Number:
[439081-17-1]
Formula:
C24H25ClFN5O3
Target:
EGFR|||p38 MAPK|||c-Met/HGFR|||Others
T72912
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