A947 is a potent and selective SMARCA2 protein hydrolysis-targeted chimeric molecule (PROTAC) that induces the degradation of SMARCA2 by binding to VHL E3 ubiquitin ligase, with significant antitumor activity in vivo and in vitro, especially in SMARCA4-mutant non-small cell lung cancer (NSCLC) cells.
Molecular Weight:
1121.4
Purity:
98.84%
CAS Number:
[2378056-80-3]
Formula:
C61H76N12O7S
Target:
PROTACs|||Epigenetic Reader Domain|||Apoptosis
T74686
T74686
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