YS-49 (monohydrate) is an isoquinoline compound alkaloid that functions as a PI3K/Akt activator, specifically targeting a downstream effect of RhoA, to mitigate the activation of RhoA/PTEN in 3-methylcholanthrene-treated cells. It also prevents the angiotensin II (Ang II)-induced proliferation of vascular smooth muscle cells (VSMCs) by promoting the expression of heme oxygenase (HO)-1. Additionally, YS-49 exerts a significant positive inotropic effect by stimulating cardiac beta-adrenoceptors, showcasing its multifaceted pharmacological activities [1] [2] [3].
Molecular Weight:
404.3
Formula:
C20H22BrNO3
Target:
Akt|||RAAS|||Others|||PI3K|||Adrenergic Receptor
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