PB118 has the capacity to effectively clear Abeta deposits by augmenting phagocytosis, enhance the tubulin/microtubule network through increased acetyl alpha-tubulin levels, modulate various inflammation-associated cytokines and chemokines, and notably diminish phospho-tau (p-tau) levels linked to Alzheimers disease (AD). The IC50 of PB118 for HDAC6 is 5.6 nM.
Molecular Weight:
314.35
Formula:
C18H19FN2O2
Target:
Others|||HDAC
T78552
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