ERD-3111 (Compound 44), an orally active PROTAC ERalpha degrader (DC50: 0.5 nM), exhibits efficacy in inhibiting tumor growth in both the parental MCF-7 xenograft model harboring wild-type ER and two ESR1-mutated mouse models. This compound has utility in the investigation of ER+ breast cancer [1].
Molecular Weight:
854.89
CAS Number:
[2832865-25-3]
Formula:
C45H46F4N8O5
Target:
PROTACs|||Estrogen Receptor/ERR
T78824
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