NF-kappaB-IN-11 (Compound 3i) is an inhibitor of NF-kappaB, effectively blocking TNF-alpha-induced NF-kappaB pathway activation and nuclear translocation of NF-kappaB, alongside reducing expression levels of phospho-IKK, IkappaBalpha, and NF-kappaB p65. Demonstrating anti-inflammatory properties, it mitigates dextran sulfate sodium-induced colitis in mice and exhibits a maximum tolerated dose (MTD) exceeding 1852 mg/kg in acute toxicity assays when administered orally (p.o.) [1].
Molecular Weight:
326.34
CAS Number:
[2768833-35-6]
Formula:
C19H18O5
Target:
NF-kappaB
T79671
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