8-Bromo NAD+ serves as a prodrug for the cyclic ADP-ribose (cADPR) inhibitor, 8-bromo cADPR, undergoing conversion to its active form by the enzyme CD38. At a concentration of 1 mM, it effectively inhibits the rise in intracellular calcium levels and chemotaxis triggered by N-formyl-Met-Leu-Phe (fMLP) in mouse bone marrow-derived neutrophils. Furthermore, when applied at 100 µM, this compound reduces LPS-induced nitrite production and decreases the secretion of TNF-alpha and IL-2 in mouse primary microglial cells.
Molecular Weight:
764.3
CAS Number:
[2022926-16-3]
Formula:
C21H25BrN7O14P2.Na
Target:
Others|||Calcium Channel
T83798
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