JQ1-FITC, a fluorescent BET bromodomain probe, exhibits high affinity binding to BRD4(BD1) and BRD4(BD2), with KD,app values of 6.5 nM and 5.8 nM respectively, as determined using GST-tagged BRD4 proteins in a CoraFluorTR-FRET assay, for BRD4(BD1), the value is 58.7 nM in a fluorescence anisotropy assay. It has excitation and emission maxima (lambda) of 495 nm and 525 nm.
Molecular Weight:
1106.58
Formula:
C50H50ClN7O9S2.CF3CO2H
Target:
Others
T83931
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