Senexin A hydrochloride functions as a selective inhibitor of CDK8/19, with an IC 50 of 280 nM for CDK8, and specifically inhibits p21-induced transcription without affecting other biological effects of p21. Additionally, it suppresses CMV-GFP induction and the stimulatory activity of the consensus NF-kappaB-dependent promoters [1] [2].
Molecular Weight:
310.78
CAS Number:
[1780390-76-2]
Formula:
C17H15ClN4
Target:
CDK|||Others
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