FGFR-IN-13 (compound III-30), an irreversible covalent inhibitor of the fibroblast growth factor receptor (FGFR), effectively modulates signaling through FGFR1 (IC 50 = 0.20 0.02 nM) and FGFR4 (IC 50 = 0.40 0.03 nM). It suppresses the expression of crucial proteins such as total-PARP and Bcl-2, while enhancing the expression of Cleaved-PARP and Bax in a dose-dependent manner. Notably, FGFR-IN-13 demonstrates considerable antitumor and oral activity [1].
Molecular Weight:
415.44
CAS Number:
[2962941-25-7]
Formula:
C23H21N5O3
Target:
FGFR
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