HDAC6-IN-37 (compound W5), an HDAC6 inhibitor, exhibits neuroprotective properties. It effectively restores the morphology of hippocampal neurons and diminishes the expression of Abeta, Tau, and p-Tau proteins in the hippocampus of AD rats. Additionally, it prevents the formation of senile plaques and neurofibrillary tangles. Consequently, HDAC6-IN-37 ameliorates the symptoms in the Abeta/Cu 2+ -induced AD rat model, regulates oxidative stress, and restores balance to neurotransmitter levels in brain tissue [1].
Molecular Weight:
385.87
CAS Number:
[2986486-82-0]
Formula:
C19H16ClN3O2S
Target:
HDAC
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