CAN508 is a potent ATP-competitive CDK9/cyclin T1 inhibitor with an IC50 of 0.35 µM. It also competitively inhibits Cdk2-cyclin E with respect to ATP, with Ki and IC50 values of 13.3 µM and 20 µM, respectively. CAN508 exhibits a 38-fold selectivity for CDK9/cyclin T over other CDK/cyclin complexes. [Antitumor activity.]
Molecular Weight:
218.22
Purity:
98.65%
CAS Number:
[140651-18-9]
Formula:
C9H10N6O
Target:
CDK
T8796
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