Pan-RAS-IN-2 (compound 6A) is an orally active molecular glue that targets RAS by inducing ternary complex formation with cyclophilin A (CYPA) and RAS in the ON state, leading to potent inhibition of downstream RAF binding and pERK signaling with an IC50 of 0.3 nM in AsPC-1 cells, Pan-RAS-IN-2 demonstrates strong antiproliferative effects in RAS-mutant cancer cell lines, supporting research into targeted therapies for colorectal and pancreatic cancers.
Molecular Weight:
837.08
Purity:
99.81%
CAS Number:
[3034673-92-9]
Formula:
C46H60N8O5S
Target:
Ras
T88116
T88116
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