PF-04802367 is a highly selective GSK-3 inhibitor with an IC50 of 2.1 nM based on a recombinant human GSK-3beta enzyme assay and 1.1 nM based on ADP-Glo assay. It shows desirable central nervous system (CNS) properties and potency. It is equally effective at inhibition of the two known GSK-3 isoforms (GSK-3alpha and GSK-3beta) with IC50 values of 10.0 and 9.0 nM in mobility shift assays, respectively.
Molecular Weight:
361.78
Purity:
98.76%
CAS Number:
[1962178-27-3]
Formula:
C16H16ClN5O3
Target:
GSK-3
T9611
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