Zaptuzumab, CAS [[2378046-35-4]] Preis auf Anfrage
Biozol Catalog Number:
TGM-T9901A-1802
Supplier Catalog Number:
T9901A-1802
Alternative Catalog Number:
TGM-T9901A-1802-1MG,TGM-T9901A-1802-5MG
Manufacturer:
TargetMol
Category:
Biochemikalien
Alternative Names:
AD5-10
Zaptuzumab (AD5-10) is a humanized monoclonal antibody targeting death receptor 5 (DR5) with high selective binding affinity. It specifically induces cancer cell death through caspase-mediated apoptosis and autophagic cell death (ACD). Zaptuzumab can activate antibody-dependent cell-mediated cytotoxicity (ADCC) and complement-dependent cytotoxicity (CDC). Additionally, it induces reactive oxygen species (ROS) production and reduces glutathione (GSH) levels. In various xenograft mouse tumor models, Zaptuzumab has demonstrated significant tumor growth inhibition and favorable safety profiles.
