Transcription factor that plays an important role in cellular development and cell survival. Recognizes and binds to the DNA sequence 5-GCG(T/G)GGGCG-3. Regulates the expression of numerous target genes, including EPO. Plays an essential role for development of the urogenital system. It has a tumor suppressor as well as an oncogenic role in tumor formation. Function may be isoform-specific: isoforms lacking the KTS motif may act as transcription factors. Isoforms containing the KTS motif may bind mRNA and play a role in mRNA metabolism or splicing. Isoform 1 has lower affinity for DNA, and can bind RNA.
Molecular Weight:
65.2 kDa (predicted)
TMPH-02312
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