DFF45 , DNA Fragmentation Factor Subunit Alpha , H13 , ICAD , DFFA , DFF1 , DFF-45 , Inhibitor of CAD , DNA Fragmentation Factor 45 kDa Subunit , DNA Fragmentation Factor Subunit alpha
DNA Fragmentation Factor Subunit Alpha (DFFA). DFFA exists as a heterodimer (DFF) with DFFB. DFF is activated once DFFA is cleaved by Caspase-3. The cleaved fragments of DFFA detach from DFFB (the active component of DFF), which in turn triggers DNA fragmentation as well as chromatin condensation during apoptosis. A reduced level of DFFA detected in ovarian endometriosis may be a part of an apoptosis-resistant mechanism enhancing the disease progression.
TMPJ-00483
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