4,5-Dimethoxycanthin-6-one is an alkaloid isolated from Picrasma quassioides BENNET (Simaroubaceae) with antimicrobial activity against Staphylococcus aureus and its drug-resistant strains. It is a potent, non-competitive inhibitor of CYP1A2-mediated phenacetin O-deethylation (IC50: 1.7 µM, Ki: 2.6 µM) and a potent inhibitor of cyclic adenosine monophosphate (cAMP) phosphodiesterase. Additionally, it exhibits cytotoxicity to tumor cell lines U937 and HepG2.
Molecular Weight:
280.28
Purity:
0.9893
CAS Number:
[18110-87-7]
Formula:
C16H12N2O3
Target:
PDE|||Cytochromes P450|||Antibacterial
* VAT and and shipping costs not included. Errors and price changes excepted
