KYL acetate is an EphA4 receptor tyrosine kinase inhibitor (Kd = 0.8 µM), inhibits EphA4-EphrinA5 interactions (IC50 = 6.34 µM). Prevents AbetaO induced synaptic damage, dendritic spine loss and prevents the blocking of LTP in hippocampal CA3-CA1 transmissions. Exhibits a long half life in cell culture media (8 and 12 hours in PC3 and C2C12 media respectively). Neuroprotective.
Molecular Weight:
1525.78
Purity:
99.75%
Formula:
C76H112N14O19
Target:
Ephrin Receptor
TP1895L1
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