Selective, high affinity, non-competitive alpha1A adrenoceptor antagonist (Ki = 0.35 nM). Exhibits no significant activity against a range of other GPCRs, including alpha2A, beta1 and beta2 adrenoceptors. Antagonizes effects of phenylephrine on isolated rabbit prostate muscle in vitro and on intra-urethral pressure in rats.
Molecular Weight:
7283.22
Formula:
C310H481N87O100S8
Target:
Adrenergic Receptor
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