N,N-Dimethylsphingosine ((2S,3R,4E)-2-(Dimethylamino)-4-octadecene-1,3-diol), CAS [[119567-63-4]]

Product Overview

• Article Name: N,N-Dimethylsphingosine ((2S,3R,4E)-2-(Dimethylamino)-4-octadecene-1,3-diol), CAS [[119567-63-4]]
• Biozol Catalog Number: USB-145682
• Supplier Catalog Number: 145682
• Alternative Catalog Number: USB-145682-10
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

Competitive sphingosine kinase (SphK) inhibitor. Exhibits inhibitory activity in platelets and in cytosolic extracts from U937, Swiss 3T3 and PC12 cells. Selectively inhibits sphingosine phosphorylation, does not inhibit N-acylation, and displays no inhibitory effect on protein kinase C at concentrations that inhibit SphK. Increases the release of IL-1beta and MCP-1 in cultured astrocytes, thought to mediate mechanical allodynia via this mechanism. Sequence: C20H41NO2 Solubility: DMSO (~30mM) Molecular Weight: ~327.55 Storage and Stability: May be stored at 4C for short-term only. Aliquot to avoid repeated freezing and thawing. Store at -20C. For maximum recovery of product, centrifuge the original vial after thawing and prior to removing the cap. Further dilutions can be made in assay buffer.

Product Properties

• Molecular Weight: 327.55
• Purity: ~98% (HPLC)
• Form: Supplied as a clear oil.
• CAS Number: [119567-63-4]