AF353 (P2X3 Purinergic Receptor Antagonist, AF353, P2X2/3 Purinergic Receptor Antagonist, AF353), CAS [[927887-18-1]]

Product Overview

• Article Name: AF353 (P2X3 Purinergic Receptor Antagonist, AF353, P2X2/3 Purinergic Receptor Antagonist, AF353), CAS [[927887-18-1]]
• Biozol Catalog Number: USB-217162
• Supplier Catalog Number: 217162
• Alternative Catalog Number: USB-217162-5
• Manufacturer: US Biological
• Category: Biochemikalien

Product Description

A novel, potent, orally bioavailable antagonist of P2X3/P2X2/3 receptors (pIC50 = 8 in human and rat, pIC50 = 7.3 for human P2X2/3 receptor). Shown to be highly brain penetrant with a brain to plasma ratio of 6. Blocks agonist-evoked intracellular Ca2+ f

Product Properties

• Purity: 99% (HPLC)
• Form: Supplied as a light brown powder.
• CAS Number: [927887-18-1]