Cytokines

High-purity cytokines for your research and drug development

Cytokines are a class of proteins produced by immune cells in response to various stimuli. The term includes interleukins (ILs), growth factors, tumour necrosis factors (TNFs), chemokines, colony-stimulating factors (CSFs) and interferons (IFNs), among others.
Cytokines play a vital role in regulating the intensity and duration of immune responses. However, under certain conditions, they can also contribute to the development of various diseases, potentially triggering a cytokine storm and cytokine storm syndrome. This can lead to damage and failure of multiple organs, and even death.

With our experienced partners we provide a comprehensive range of validated high-purity cytokines for your research and drug development.

ABclonal

Cytokines for Macrophage Culture

macrophage-polarization Cytokines play a decisive role in the success of macrophage cultures and polarisation experiments. Scientists often encounter quality problems, e.g. inconsistent purity and activity, resulting in suboptimal polarisation and poor reproducibility of data.

Unlock the power of recombinant cytokines in macrophage culture! Recombinant cytokines from ABclonal come with high purity, low endotoxin content, validated bioactivity, and a high batch-to-batch consistency.

Product Highlights:

Art N°	Product description
ABB-RP01216	Active Recombinant Mouse CSF-1/M-CSF Protein
ABB-RP01161	Recombinant Mouse IL-4 Protein
ABB-RP01465	Recombinant Mouse IL-10 Protein
ABB-RP01070	Recombinant Mouse IFN-gamma Protein

>> ABclonal in the BIOZOL web shop

Acro Biosystems

Broad Range of recombinant Cytokines

AcroBiosystems offers you a range of recombinant cytokines and their receptors with high purity, high bioactivity and high batch-to-batch consistency to accelerate your scientific research and drug development programmes.

Features of AcroBiosystems' cytokines: Role of Cytokines in tumors

Closer to the natural conformation in humans, as expressed by HEK293 cells
Different species: human, mouse, rat, Javan monkey/cynomolgus, rhesus monkey, rabbit, dog, suitable for cross-species experiments
Various labels and tags/markers
Biotinylated cytokines are produced exclusively with AvitagTM technology:
- Biotinylation occurs only at the lysine residue of the Avi tag
- No interference with the natural binding activities of the target protein
- The orientation of the protein is uniform when immobilised on an avidin-coated surface
The high purity and homogeneity of the structure is confirmed by both SDS-PAGE and SEC-MALS
The high bioactivity of binding to the receptor or antibody is confirmed by ELISA/SPR/BLI/cell-based assays. Procedural guidelines are available
Strict quality control to ensure high batch-to-batch consistency (ELISA as QC assay)
More comprehensive cytokine products, up-to-date cytokine targets are available

>> AcroBiosystems in the BIOZOL web shop

BioLegend

Cytokines, Chemokines, and Growth Factors

Cytokines allow cells to communicate with one another and induce a wide range of activities. They can be pro- or anti-inflammatory, promote cell growth, or influence differentiation to various cell types. To mediate these functions, cytokines bind to their respective receptors on the cell surface, initiating signaling cascades for gene transcription. For example, Naïve CD4+ T cells can give rise to a number of T helper classes, depending on the recombinant proteins used to induce differentiation. Chemokines are relatively small cytokines which regulate cell movement, also known as chemotaxis.

Growth factors are a broad family of proteins that regulate a number of important cellular processes including cell growth, differentiation, proliferation, and survival. Growth factors bind to transmembrane receptors typically containing a cytoplasmic tyrosine kinase domain which initiates downstream signaling pathways including MAP kinase and PI3K-mTOR pathways.

BioLegend offers a large range of recombinant cytokines, chemokines, and growth factors. Their LEGENDplex flow cytometry assays are built and optimized for convenient multi-target cytokine analysis.

>> BioLegend in the BIOZOL web shop

PBL Assay Science

Cytokines and Growth Factors

Cytokines are a class of signaling proteins that play a role in both the induction and effector phases of all immune and inflammatory responses, including cell proliferation, intercellular communication, and cell death. Cytokines are produced by a variety of hematopoietic and non-hematopoietic cell types and can exert autocrine and paracrine effects. They are related more correctly to hormones than to growth factors in their overall functions, but many cytokines also exhibit growth factor activity.

Growth factors are proteins that bind to receptors on the cell surface, with the primary result of activating cellular proliferation and/or differentiation. Growth factors are important for regulating a variety of cellular processes and are quite versatile, stimulating cellular division in numerous different cell types; while others are specific to a particular cell-type.

PBL Assay Science offers E.coli and CHO expressed cytokines and growth factors, as well as human cell-expressed (HCE) cytokines, closely mimicing native human proteins.

>> Type I and Type II Interferons: High-purity proteins, sensitive ELISA kits

>> PBL Assay Science in the BIOZOL web shop

Raising the standard in bioactive protein manufacturing

Qkine is committed to manufacturing bioactive proteins of the highest quality to enhance scientific outcomes and improve reproducibility. Their robust animal-free manufacturing platform, along with rigorous quality control procedures, ensures exceptional bioactivity and consistent performance from lot to lot, guaranteeing outstanding performance in your applications.

Qkines product portfolio comprises growth factors and cytokines tailored for stem cell and organoid culture, as well as biomarkers and attachment factors. Qkine actively supports emerging fields such as cellular agriculture, regenerative medicine, synthetic hydrogels, organ-on-a-chip technology, and bioprinting.

>> Human Pluripotent Stem Cells: Differentiation Guide from Qkine

>> Qkine in the BIOZOL web shop

Next-Generation Cytokines for Immunotherapy

Cytokines are small proteins that play a crucial role in regulating the growth, differentiation, and activation of immune cells, making them essential for immune system functioning. Cytokines can inhibit tumor growth by direct antiproliferative effects or by stimulating immune cells to attack tumor cells. This also reveals their great potential in cancer immunotherapy. However, the use of natural cytokines in therapy has been limited by their short half-life, systemic toxicity, and lack of specificity.

First-generation cytokines like IL-2 and IFN-α have been pivotal in cancer immunotherapy. IL-2 was approved for advanced renal cell carcinoma and metastatic melanoma treatment, while IFN-α for hairy cell leukemia, follicular non-Hodgkin lymphoma, melanoma, and AIDS-related Kaposi’s sarcoma. However, their clinical use is hindered by short in vivo half-life, severe toxicity at therapeutic doses, and limited efficacy in most patients Next-generation cytokines are engineered to improve upon the properties of their predecessors. These innovations include enhanced stability, reduced toxicity, and increased specificity for tumor cells.

Sino Biological provides an extensive range of recombinant cytokines for cell culture, enhancing research in tumor immunotherapy, stem cell therapy, drug screening, and regenerative medicine. Our products undergo stringent quality control and thorough validation to ensure high purity, biological activity, stability, and low endotoxin levels. Committed to delivering high-quality reagents for drug development and clinical research, Sino Biological offers both research-use-only (RUO) and GMP-grade cytokines.

>> Sino Biological in the BIOZOL web shop

back to the top