Journal Clubs: Neuropathology of patients with COVID-19 in Germany: a post-mortem case series
The Lancet, 2020
Prominent clinical symptoms of COVID
-19 include CNS manifestations. However, it is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID
-19, gains access to the CNS and whether it causes neuropathological changes. Here, Matschke et al. investigated the brain tissue of patients who died from COVID
-19 for glial responses, inflammatory changes, and the presence of SARS-CoV-2 in the CNS. The group detected fresh territorial ischaemic lesions in...