Inflammasome Activation

NEK7: An Essential Regulator of NLRP3

Inflammasomes are multiprotein complexes, responsible for the activation of inflammatory responses. Inflammasome activation is initiated by various cytosolic pattern recognition receptors (PRRs), including the NLR family of receptors. The NLRP3 inflammasome assembles NLRP3, ASC, and pro-caspase-1, leading to the activation of caspase-1, the cleavage and secretion of interleukin 1β (IL-1β) and interleukin 18 (IL-18) in response to diverse stimuli.

NEK7 is the smallest of the eleven (NEK1-NEK11) mammalian NIMA-related kinase (NEK) family serine/threonine kinases and is expressed in many tissues. Its importance in mitotic regulation and NLRP3 inflammasome activation has been established, with inflammasome activation involving NEK7’s direct binding to NLRP3. Inflammasome activation is associated with pyroptosis and mediates the release of pro-inflammatory cytokines IL-1β and IL-18 and the cleavage of pore-forming gasdermin D. Pyroptosis is linked to many inflammatory diseases, and thus therapeutic targeting of NEK7-mediated inflammasome activation continues to be an exciting field of research (1).

GeneTexOur partner GeneTex offers a diverse selection of high-quality reagents to study inflammation. These antibodies are validated for various applications, including western blot, ICC/IF, and IHC-P.

 

Highlighted Products

 

NEK7 antibody [HL1348]
Art. Nr. GTX636768
NLRP3 antibody
Art. Nr. GTX133569
IL1 beta antibody [HL1421]
Art. Nr. GTX636887
Gasdermin D antibody [HL1430]
Art. Nr. GTX636896

 

Reference: Front Physiol. 2020; 11: 606996. 

21.09.2022

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