RAS genes in development and cancer
We would like to invite you to participate in our partner company GeneTex's upcoming webinar on RAS genes in development and cancer.
Webinar: RAS genes in development and cancer
RAS genes have gained prominence due to their implication in human cancer. Mammals harbor three RAS loci (HRAS, NRAS and KRAS) that are found mutated in many different tumor types, albeit with clear tissue-selective preferences for individual RAS loci. Moreover, whereas HRAS and NRAS produce only one major protein, the KRAS locus gives rise to two different protein isoforms via alternative splicing of the final exon. Thus, all four RAS proteins differ in the C-terminal hypervariable region that determines how RAS proteins are anchored to the cell membrane. Despite these differences, RAS proteins share common biochemical features and participate in similar activities. In his webinar, Dr. Drosten will focus on three fundamental aspects of RAS biology:
- What is the biological difference between the three RAS genes and what is their role in normal homeostasis?
- What is the (differential) role of RAS paralogs in cancer?
- What are the contributions of each of the KRAS isoforms to development and cancer?
He will explain how mouse models have been crucial in revising some of the classical concepts of RAS biology.
Speaker: Matthias Drosten, Cancer Research Center (CIC), Salamanca (Spain)
Date and Time: Wednesday, October 5, 2022, 4 PM CEST
GeneTex provides a growing selection of quality reagents for cancer research, among these antibodies directed against key factors involved in tumorigenesis and metastasis.