Cardiovascular Biomarkers

Antibodies, Proteins, and ELISA Kits for clinical research

Cardiovascular diseases are the most common cause of death worldwide and in Germany. However, if diagnosed in time, these diseases can usually be treated well. From vascular inflammation, endothelial function, and coagulation to heart failure, cardiac damage, and preclinical safety testing, academic laboratories require reliable reagents, validated assays, and robust detection systems to precisely investigate disease mechanisms and efficiently advance translational research.

BIOZOL supports your research with selected products from established manufacturers, including staining reagents for vascular and tissue analysis, ELISA kits for cardiac and inflammatory biomarkers, specialized immunoassays for biomarker research, antibodies, proteins, and assays.

Alpco

ELISA Kits for Cardiovascular Biomarkers

Alpco is a leading global developer and provider of molecular and immunodiagnostic products focused on infectious and gastroenterological diseases.

For cardiovascular research, Alpco provides high-quality ELISA Kits measuring renin, fibrinogen, and hemopexin in different species:

Art. N°	Product Description
ACD-20-RENHU-E01	Renin ELISA
ACD-11-RNNHU-E02	Renin Activity ELISA
ACD-41-FIBHU-E01	Fibrinogen ELISA
ACD-41-FIBMS-E01	Mouse Fibrinogen ELISA
ACD-41-FIBPO-E01	Porcine Fibrinogen ELISA
ACD-41-HMPHU-E01	Hemopexin ELISA
ACD-41-HMPMS-E01	Mouse Hemopexin ELISA
ACD-41-HMPRT-E01	Rat Hemopexin ELISA

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Specialized Immunoassays for Cardiovascular Biomarkers

Biomedica develops quality proved immunoassays for research and medical diagnostics with a focus on cardiology, nephrology and bone metabolism. The production is ISO-certified.

FGF23: Novel Risk Marker of Heart Failure

FGF23 (fibroblast growth factor 23), a known marker of phosphate metabolism, has acquired independent importance in the cardiovascular system (Hu et al. 2013). Recent studies indicate that FGF23 is also expressed in the heart (Itoh et al., 2016). Elevated FGF23 levels are associated with cardiovascular mortality, higher risk of myocardial infarction, stroke, and heart failure. In addition, there is growing evidence that FGF23 levels may predict response to therapies to reduce the risk of heart failure (Brandenburg et al., 2014; Almahmoud et al., 2018). Further clinical studies are needed, but FGF23 is one of the few promising biomarkers that have the potential to determine the effect of FGF23-specific therapeutic interventions on clinically relevant endpoints (Vervloet et al., 2019).

Premium ELISA Kits for FGF23 detection:

BI-20700	Biomedica FGF23 (intact) human ELISA
BI-20702	Biomedica FGF23 (C-terminal) multi-matrix ELISA

big ET for the diagnosis of Heart Failure with preserved Ejection Fraction (HFpEF)

Renal dysfunction may limit the clinical application of NT-proBNP in the diagnosis of heart failure. Big ENDOTHELIN (big ET) is an excellent biomarker candidate for the diagnosis of HFpEF in CKD, independent of GFR (Gergei et al., 2018). NT-proBNP is strongly associated with GFR and shows an exponential negative correlation with GFR decline, whereas Big ET-1 is much less affected. A single cut-off point is sufficient in the diagnosis of HFpEF in CKD.

BI-20082H

Biomedica Big Endothelin ELISA

Other cardiovascular biomarker ELISA test kits for clinical and preclinical use:

BI-20892	Biomedica NT-proANP ELISA
BI-20812	Biomedica NT-proCNP ELISA
BI-20403	Biomedica OPG ELISA

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Biorbyt

SERCA regulator DWORF

DWORF has emerged as a key regulator of cardiac calcium homeostasis by enhancing Sarcoplasmic/Endoplasmic Reticulum Calcium ATPase (SERCA) activity and supporting efficient calcium reuptake in cardiomyocytes. As disrupted calcium cycling is a hallmark of heart failure and dilated cardiomyopathy, DWORF has gained significant attention as a promising biomarker and therapeutic target in cardiovascular research. High-quality DWORF reagents enable researchers to investigate its biological function, signaling pathways, and potential role in the development of novel heart failure therapies.

Biorbyt provides high-purity recombinant human DWORF proteins for your research:

Art. N°	Product Description
BYT-ORB3007699	Recombinant Human SERCA regulator DWORF, partial
BYT-ORB3008932	Recombinant Human SERCA regulator DWORF, partial, Biotinylated
BYT-ORB3006467	Recombinant Human SERCA regulator DWORF, partial, Biotinylated
BYT-ORB3005234	Recombinant Human SERCA regulator DWORF, partial
BYT-ORB3011390	Recombinant Human SERCA regulator DWORF, partial
BYT-ORB3010160	Recombinant Human SERCA regulator DWORF, partial

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BioVendor

In vitro diagnostic and for-research-use immunoassays

BioVendor is focused on developing and manufacturing in vitro diagnostic and for-research-use immunoassays, antibodies and recombinant proteins.

Highlighted assays for cardiovascular diseases:

Art. N°	Product Description
BVD-RD194015200R	Interleukin-6 Human ELISA (CE-IVD)
BVD-RD194559200R	Interleukin-1 beta Human ELISA
BVD-RD191037100	Fetuin-A (AHSG) Human ELISA (CE-IVD)
BVD-RBL005R	Human GDF-15 ELISA
BVD-RBL001R	Human MMP-2 ELISA
BVD-RBL002R	Human MMP-9 ELISA
BVD-RBL031R	Human sST2 ELISA

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Cloud-Clone

Multiplex Assays for Cardiovascular-Related Pathways

The formation and development of heart and blood vessel, as well as the repair of injury and aging are regulated by many systems. Once these regulatory systems are become disordered, it will inevitably lead to metabolic disorders of heart and blood vessel cells, including the occurrence of cardiovascular diseases. According to current research, there are many cardiovascular-related signaling pathways.

Common cardiovascular-related pathways:

ENOS/NO signaling pathway: As a signal molecule, nitric oxide plays an important role in regulating blood pressure, maintaining vascular tension and regulating immune system in physiological activities. Abnormal NO is the cause of many cardiovascular diseases. Endothelial nitric oxide synthase, eNOS plays a major regulatory role as a rate-limiting enzyme in inducing NO synthesis.
Hippo-YAP signaling pathway: It plays a significant regulatory role in cell proliferation and apoptosis, and its core members include YAP and other proteins.
IL-33/ST2 signaling pathway: Soluble ST2 protein (sST2) is a member of the lL-1 receptor family, which can block the anti-cardiomyocyte hypertrophy and myocardial fibrosis effects of lL-33, leading to myocardial remodeling.
MTOR signaling pathway: mTOR kinase is an essential fator in regulating the homeostasis and growth of cardiomyocytes during development and postnatal period.
NOTCH signaling pathway: Notch signaling can be partly responsible for a variety of physiological processes, such as angiogenesis, myogenesis, neurogenesis and hematopoiesis, and determine the growth, differentiation and survival of various cell types in different tissues.

Cloud-Clone provides a wide range of multiplex assay kits to support your research on cardiovascular diseases.

Selected Multiplex Assay Kits for Cardiovascular-Related Pathways:

Art. N°	Product Despription
USC-IS135-39	Multiplex Assay Kit for Human ANGPT1, ANGPT2, FGF1, HIF1a, HIF2a, VEGFA, VEGFB, 7-Plex
USC-IS135-125	Multiplex Assay Kit for Human IL1a, IL1b, IL6, IL10, IL17, MCP1, TNFa, 7-Plex
USC-IS135-162	Multiplex Assay Kit for Mouse BNP, IL10, IL17, IL1b, IL4, IL6, TNFa, 7-Plex
USC-IS135-160	Multiplex Assay Kit for Mouse BDNF, GDNF, MCP1, PLGF, TNFa, VEGFA, 6-Plex
USC-IS135-163	Multiplex Assay Kit for Mouse BNP, IL10, IL1a, IL1b, IL33, IL6, TNFa, TNNI3, 8-Plex

>> Cloud-Clone in the BIOZOL web shop

Cusabio

Recombinant Proteins for Cardiovascular Diseases Research

Cardiovascular diseases (CVD) refer to a group of disorders of the heart and blood vessels, including atherosclerosis, cardiac arrhythmias, cardiomyopathy, heart failure, hypertension, coronary diseases, coagulative disorders, and more. Cusabio has been committed to developing and expanding the featured area (including cardiovascular, cancer, immunology, signal transduction, neuroscience, epigenetics etc.), where tehy have the most comprehensive products and the strongest cooperation channels.

Common Cardiovascular Diseases

Atherosclerosis is the narrowing of arteries caused by the buildup of fatty plaques, typically containing LDL cholesterol, smooth muscle cells, fibrous tissue, and sometimes calcium. Artherosclerosis is the main cause of coronary heart disease, cerebral infarction, and peripheral vascular disease.
Coronary Artery Disease (CAD) develops when the coronary arteries become damaged or diseased. CAD then causes by a buildup of plaque in coronary arteries.
Heart attack (myocardial infarction) occurs when the flow of blood to the heart is blocked. It most often causes by a build-up of fat, cholesterol and other substances, which form a plaque in the coronary arteries.
Stroke is usually divided into ischemic stroke and hemorrhagic stroke. An ischemic stroke occurs when a blood vessel that feeds the brain gets blocked, usually from a blood clot. A hemorrhagic stroke occurs when a blood vessel within the brain bursts. This is most often caused by uncontrolled hypertension (high blood pressure).

Popular Recombinant Proteins for Cardiovascular Diseases Research:

Recombinant Human NPR1

(Art. N° CSB-YP016023HU)

Recombinant Human GLP1R

(Art. N° CSB-EP009514HU)

Recombinant Human ADIPOR1

(Art. N° CSB-CF001367HU)

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Elabscience

High Quality ELISA Kits for Cardiovascular Research

Elabscience® has been specializing in immunoassay products for 14 years and provides researchers with a wide range of high-quality ELISA Kits, CLIA Kits, Matched Antibody Pair Kits and Food Safety Kits. The products can be used on a range of species, including human, mouse, rat, rabbit, monkey, universal and more.

Why choose Elabscience ELISA Kits

High precision: both inter and intra CV <10%
High sensitivity: Pg level
Good specifity: cross-reactivity <10%
Covering various targets and species
Flexible choices on size: 48T/98T/96T*5/96T*10
One-step method available

For cardiovascular research, Elabscience® provides high quality ELISA kits to study multiple aspects of the cardiovascular system, including angiogenesis, blood pressure regulation, cholesterol metabolism, artherosclerosis, and more.

Selected Cardiovascular Marker ELISA Kits:

Target	Art. N°	Species
ACE (Angiotensin I Converting Enzyme)	ELA-E-EL-M3013 / ELA-E-EL-R2401	Mouse/Rat
BMP-2 (Bone Morphogenetic Protein 2)	ELA-E-EL-H0011 / ELA-E-EL-M0193 / ELA-E-EL-R0002	Human/Mouse/Rat
FABP3 (Fatty Acid Binding Protein 3, Muscle and Heart)	ELA-E-EL-H1431	Human
TM (Thrombomodulin)	ELA-E-EL-H0166	Human
VE-Cadherin (Vascular Endothelial Cadherin)	ELA-E-EL-H6103	Human
VEGFR-2/KDR (Vascular Endothelial Growth Factor Receptor 2)	ELA-E-EL-H1603 / ELA-E-EL-M0649	Human/Mouse

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Vector Laboratories | Everest LS Bio Absolute Antibody Kerafast

Popular Research Reagents for Cardiovascular Research

Vector Laboratories, together with their brands Everest, LS Bio, Absolute Antibody, and Kerafast provide a wide range of popular research reagents for cardiovascular research, including antibodies, proteins, and ELISA kits for myocardial injury detection, heart failure & cardiac remodeling, lipoproteins, atherosclerosis & inflammation, and thrombosis & coagulation research.

Myocardial Injury Detection

Antibodies and ELISA kits that support investigation of early myocardial injury pathways, biomarker kinetics, and multi-marker strategies for myocardial infarction (MI).

Featured Products:

Art N°	Product Description
EVE-EB11810	Goat Anti-cardiac troponin T Antibody
EVE-EB11809	Goat Anti-cardiac troponin T (aa201-213)
LS-F24180	Mouse TNNI3 / Cardiac Troponin I (Sandwich ELISA)
LS-F5248	Human Copeptin (Competitive EIA)

Heart Failure & Cardiac Remodeling

Antibodies and proteins for use in studies of extracellular matrix remodeling and fibrosis.

Featured Products:

Art N°	Product Description
LS-B10948	IHC‑plus™ Polyclonal Rabbit anti‑Human Osteoglycin / Mimecan
LS-C740696	Polyclonal Rabbit anti‑Mouse Osteoglycin / Mimecan
LS-G15022	Human Osteoglycin / Mimecan Protein (Recombinant His) (aa180-298)
LS-G21024	Human Osteoglycin / Mimecan Protein (Recombinant His) (aa21-298)

Lipoproteins, Atherosclerosis & Inflammation

Antibodies and ELISA kits that aid research into lipid biology, vascular inflammation, endothelial dysfunction, and plaque-associated processes.

Featured Products:

Art N°	Product Description
ABA-AB00715	Anti-VEGF [Bevacizumab] Research-Grade Biosimilar
LS-C104524	Polyclonal Rabbit anti‑Mouse VEGFA / VEGF
LS-F21752	Human LPA / Lipoprotein a (Sandwich ELISA)
LS-F27736	Human LPA / Lipoprotein a (Competitive EIA)

Thrombosis & Coagulation

Antibodies that enable investigation of platelet activation pathways, integrin signaling, and thrombus formation mechanisms.

Featured Products:

Art N°	Product Description
KER-EBW105	Anti-Glycoprotein GPIIIa/GPIIb Complex [AP-2]
KER-EBW108	Anti-Integrin Beta 3 (GPIIIa, CD61) [MBC 319.4]
KER-EBW106	Anti-Integrin Beta 3 (GPIIIa, CD61), PSI Domain [AP-3]