Immune Checkpoint Markers

Outstanding PD-L1 Antibody from GeneTex for your Research

Increasing knowledge of how cancer cells escape immune destruction has significantly driven the evolution of cancer immunotherapy. In particular, studies describing how different immune checkpoints, including the PD-1 and CTLA-4 pathways, function to attenuate T cell antitumor activity have revealed novel opportunities for therapeutic intervention. Researchers have made promising strides in inhibiting these checkpoints to unleash the T cells’ tumor-killing potential. Given that both radiotherapy and chemotherapy can also mobilize antitumor T cells, there is great excitement that checkpoint inhibition and other immunomodulatory approaches can be combined with conventional modalities to maximize clinical outcomes for a number of malignancies.

Our partner GeneTex proudly provides an outstanding PD-L1 antibody for your research.


PD-L1 antibody


PD-L1 antibodies recognize programmed death-ligand 1 (PD-L1) protein, also known as B7 homolog 1 (B7-H1) and cluster of differentiation 274 (CD274) protein. PD-L1 is found on various cancer cells and transduces immunosuppressive signals by binding to the programmed cell death protein 1 (PD-1) on effector T cells, thereby diminishing immune system attacks on malignant cells. Blocking the interaction between PD-L1 and PD-1 with PD-L1 antibodies is generating great clinical interest as a mode of immunotherapy against a number of cancers.

The much-cited PD-L1 antibody from GeneTex (Art. Nr. GTX104763), used at 1:1000 for IHC, is highly specific and sensitive, as shown by knockout/knockdown validation.




Target Specificity



Further GeneTex antibodies for your immune checkpoint research:


IDO1 antibody (GTX113753)

Galectin 3 antibody (GTX113486)

HMGB1 antibody (GTX101277)

GeneTex offers 10 µl antibody samples of these products for trial.


More information on Immune Checkpoint Markers:

>> News: Adaptive Immunity - HLA-G antibody panel for flow cytometry

>> Journal Club: The RANK Pathway as an Immune Modulator in Breast Cancer

>> Journal Club: HLA-G and HLA-E Immune Checkpoints Are Widely Expressedin Ewing Sarcoma



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