GFAP: Marker of Astrocyte Activation

GeneTex recombinant rabbit monoclonal antibodies

Glial fibrillary acidic protein (GFAP) is a signature intermediate filament (IF) in astrocytes, that contributes to synapse formation and axonal metabolic homeostasis in the CNS. GFAP induction is crucial for the formation of extended and thickened astrocytic processes (astrocytosis) during neural repair. Chronic reactive astrocytosis is linked to several neuroinflammatory and neurodegenerative diseases, including Alzheimer’s disease and Parkinson’s disease. In 2018, the FDA authorized the first blood test to evaluate mild traumatic brain injury (mTBI) through measurement of GFAP and the neuroaxonal marker ubiquitin carboxy-terminal hydrolase L1 (UCHL1, PGP9.5) (1). Emerging evidence also indicates that plasma GFAP may be a useful marker of disease severity in multiple sclerosis (2).

GeneTexGeneTex has introduced a series of recombinant rabbit monoclonal antibodies against GFAP and other key neurobiology proteins (see below) that expands its already broad catalog of well-validated conventional monoclonal and polyclonal antibodies for neuroscience research.

 

Product Highlights

GFAP antibody [HL1307] (Art. Nr. GTX636725)

This gene encodes one of the major intermediate filament proteins of mature astrocytes. It is used as a marker to distinguish astrocytes from other glial cells during development.

Iba1 antibody [HL22] (Art. Nr. GTX635363)

This gene encodes a protein that binds actin and calcium. This gene is induced by cytokines and interferon and may promote macrophage activation and growth of vascular smooth muscle cells and T-lymphocytes.

Myelin basic protein antibody [HL1033] (Art. Nr. GTX635873)

The protein encoded by the classic Mbp gene is a major constituent of the myelin sheath of oligodendrocytes and Schwann cells in the nervous system. However, Mbp-related transcripts are also present in the bone marrow and the immune system.

AChE antibody [HL1102] (Art. Nr. GTX636298)

Acetylcholinesterase hydrolyzes the neurotransmitter, acetylcholine at neuromuscular junctions and brain cholinergic synapses, and thus terminates signal transmission.

References:

  1. FDA authorizes marketing of first blood test to aid in the evaluation of concussion in adults | FDA
  2. Front Neurol. 2019 Mar 26;10:280. doi: 10.3389/fneur.2019.00280.

 

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20.10.2022

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