Immune checkpoints are regulators of the immune system which prevent the immune system from attacking self-antigens indiscriminately.  While this is critical to preventing auto-immune disease it also causes the immune system to be ineffective in eradicating or suppressing cancer. Tumor cells exploit certain immune-checkpoint pathways as a major mechanism of immune resistance, particularly against T cells that are specific for tumor antigens. Because many of these immune checkpoints are initiated by ligand-receptor interactions, they can...

PathPlus™ antibodies from LifeSpan  Biosciences (LSBio) represent the highest quality reagents available for research pathology applications. These reagents were selected from among thousands of antibodies, tested in immunohistochemistry on formalin...

DNA is a macromolecule capable of adopting many different conformations. In addition to the canonical Watson-Crick B-DNA, at least another 10 different conformations have been identified, with Z-DNA in particular attracting more and more attention (Wang et al., 2007). Z-DNA...

Monovalent Fab fragments of affinity-purified secondary antibodies are offered to block endogenous immunoglobulins, to cover immunoglobulins when double labeling primary antibodies from the same host species, or to Fab-label primary antibodies prior to incubation with the experimental sample. ...

Bio X Cell offers InVivoPlus™ versions of our most popular InVivoMAb™ products. The InVivoPlus™ versions of their products are structurally and functionally identical to the InVivoMAb™...

We invite you to join our partner Sino Biological's upcoming scientific webinar on current methods of recombinant antibody production.     Recombinant Antibody Production: Current Methods and a Novel Antibody Generation Platform Antibodies are bio-macromolecules that bind to the...

It was a great pleasure for us to welcome you in such large numbers at the BIOZOL booth at this year's Analytica in Munich. Thank you to all our visitors for the good conversations and impulses! Especially our donation wheel was again very popular: Here our visitors could spin amounts between 1 and 18 Euro, and then choose one of three research organizations to which BIOZOL will donate these amounts.&n...

We invite you to join our partners Atlas Antibodies', MBL's, and GeneTex' upcoming scientific webinars. Learn about Isotype Control Selection, Spatial Proteomics in health and disease, and stem cell regeneration.     The Human Protein Atlas -Spatial proteomics in health and d...

As the leading manufacturer of zebrafish antibodies, our partner GeneTex offers a catalog of 360 primary antibodies validated for essential applications. >> Browse GeneTex' Zebrafish Antibodies

A growing number of immune checkpoints emerge as targets for anticancer therapy. So far, PD-1 and CTLA-4 emerged as the most successful immune targets for anticancer therapies. The recently discovered TIGIT pathway provides significant therapeutic promise, particularly in combination with other immune checkpoint inhibitors. In the healthy immu...