This webinar, sponsored by Sino Biological and hosted by the Cambridge Healthtech Institute (CHI), informs about the latest research and technologies for COVID-19 vaccine development. Topics and Speakers:
GeneTex Webinar: COVID-19 and the Brain Presented by: GeneTex Speaker: Dr. Eric Song, Yale University Content Dr. Eric Song of Yale University discusses his work that revealed the ability of SARS-CoV-2 to directly infect the mammalian brain...
Join GeneTex’s senior scientist Alexander Ball, M.D. for an overview of the scientific and clinical aspects of SARS-CoV-2/COVID-19 along with an introduction to GeneTex’s SARS-CoV-2 and coronavirus catalog of reagents. Content: Origin of SARS-CoV-2 Global situation B...
A subset of COVID-19 patients experience cytokine storm syndrom with elevated levels of inflammatory cytokines in the lungs, leading to tissue damage. To assess these cytokines, researchers can use multiplex assays, like BioLegend's LEGENDplex™, to quantitate the factors made in response to SARS-CoV-2 infection. Understanding what drives severe t...
Accelerate COVID-19 Antibody Development via Single B Cell Screening Presented by: Genscript Inc. Speaker: Dr. Pei Liu, Senior Scientist, Antibody Department Content In working towards developing a COVID-19 antibody testing solution, we combined the unique advantages...
Enzymes catalyze a number of important biological reactions. In the context of SARS-CoV-2, they are vital for viral entry and replication. Learn more about the key enzymes utilized by this virus and potential therapeutics to block them.
In this talk, Dr. Ordovas-Montañes will discuss recent studies utilizing single-cell genomics to comprehensively map the cell types, subsets, and states that compose human barrier tissues. He will present findings related to health and disease in the nasal and intestinal mucosa and recent work to understand the potential cellular targets...
This webinar discusses the approaches used to screen for SARS-CoV-2 (2019-nCoV) neutralizing antibodies and evaluate their bioactivity in vitro. Speaker: Dong Li, Ph.D., Senior Scientist at Sino Biological Inc.
Host Cell Protein Analysis by ELISA and Orthogonal Methods in Vaccine and Gene Therapy Development Presented by Cygnus Technologies Speaker: Jared Isaac, Ph.D, Sr. Scientist, Cygnus Technologies LLC Content
Emergence of New SARS-CoV-2 Variants & Resistance to Antibody Neutralization
Presented by: The Scientist Sponsored by: SinoBiological, BioLegend, AcroBiosystems Speakers: Prof. Dr. Alessandro Sette, and Prof. Shane Crotty, PhD, La Jolla Institue for Immunology Content Many immunologists are looking at T cell...
Presented by: Immunostep Speakers: Óscar Gala Sánchez Content During this webinar we aimed to understand how a serological assay by flow cytometry works allowing us to detect 3 immunoglobulins against 4 viral proteins simultaneously. We also showed how this multiplex SARs-CoV...
Webinar: Vaccine...COVID-19 immune responses using FluoroSpot.
SUMMARY The outbreaks of 2019 novel coronavirus disease (COVID-19) caused by SARS-CoV-2 infection have posed asevere threat to global public health. It is unclear how the human immune system responds to this infection.Here, we used metatranscriptomic sequencing to profile immune signatures in the bronchoalveolar lavage fluidof eight COVID-19 cases. The expression of proinflammatory genes, especially chemokines, was markedlyelevated in COVID-19 cases compared to community-acquired pn...
Prominent clinical symptoms of COVID-19 include CNS manifestations. However, it is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), the causative agent of COVID-19, gains access to the CNS and whether it causes neuropathological changes. Here, Matschke et al. investigated the brain tissue of patients who died from COVID-19 for glial responses, inflammatory changes, and the presence of SARS-CoV-2 in the CNS. The group detected fresh territorial ischaemic lesions in...
Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is the cause of an ongoing pandemic, with increasing deaths worldwide. To date, documentation of the histopathological features in fatal cases of the disease caused by SARS-CoV-2 (COVID-19) has been scarce due to sparse autopsy performance and incomplete organ sampling. Bradley at al. aimed to provide a clinicopathological report of severe COVID-19 cases by documenting histopathological changes and evidence of SARS-CoV-2 tissue trop...
Abstract Activation of the RIG-I-like receptors, retinoic-acid inducible gene I (RIG-I)...COVID-19 pandemic. Our work demonstrates a crucial role for ISG15 in the MDA5-mediated antiviral response, and also identifies a key immune evasion mechanism of SARS-CoV-2, which may be targeted for the development of new antivirals and vaccines to combat COVID-19. GeneTex SARS-CoV-2 (COVID-19) antibodies GTX135589 (SARS-...
A team of scientists, including researchers from Active Motif China, developed recombinant antibodies targeting SARS-CoV-2 and their work was recently published in the journal Cell Reports. Several of these antibodies were strong binders to the SARS-CoV-2 Spike S1 protein and were able to effectively neutralize infectivity of the virus, suggesting that they could be further developed and used as therapeutics against COVID-19. Learn in the following article how Wan et al. identified...
Summary COVID-19, caused by SARS-CoV-2, is a virulent pneumonia, with >4,000,000 confirmed cases worldwide and >290,000 deaths as of May 15, 2020. It is critical that vaccines and therapeutics be developed very rapidly. Mice, the ideal animal for assessing such interventions, are resistant to SARS-CoV-2. Here, we overcome this difficulty by exogenous delivery of human ACE2 with a replication-deficient adenovirus (Ad5-hACE2). Ad5-hACE2-sensitized mice developed pneumonia char...
Abstract The emergence of a new severe acute respiratory syndrome coronavirus...COVID-19) nucleocapsid antibody, GTX635679 SARS-CoV-2 (COVID-19) nucleocapsid antibody [HL344] and GTX632604 SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9].
As described in their recent Cell study, Hoffmann et al. identified the serine protease TMPRSS2 as a critical factor in the priming of the SARS-CoV-2 spike protein with its receptor ACE2, and demonstrated that a clinically proven protease inhibitor, camostat mesylate, is able to interfere with SARS-CoV-2 infection of lung cells. Featured Products: SARS-CoV / SARS-CoV-2 (COVID-19) spike antibody [1A9] (
The SARS-CoV-2 pandemic affecting the human respiratory system severely challenges public health and urgently demands for increasing our understanding of COVID-19 pathogenesis, especially host factors facilitating virus infection and replication. SARS-CoV-2 was reported to enter cells via binding to ACE2, followed by its priming by TMPRSS2. Here, we investigate ACE2 and TMPRSS2 expression levels and their distribution across cell types in lung tissue...
Vaccines to prevent coronavirus disease 2019 (Covid-19) are urgently needed. The effect of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) vaccines on viral replication in both upper and lower airways is important to evaluate in nonhuman primates. In this study, nonhuman primates received 10 or 100 μg of mRNA-1273, a vaccine encoding the prefusion-stabilized spike protein of SARS-CoV-2, or no vaccine. Antibody and T-cell responses were assessed before upper- and lowe...
Abstract The host cell serine protease TMPRSS2is an attractive therapeutic target for COVID-19 drug discovery. This protease activates theSpike protein of Severe Acute Respiratory Syndrome
COVID-19, caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has become a global pandemic and has claimed over 2 million lives worldwide. Although the genetic sequences of SARS-CoV and SARS-CoV-2 have high homology, the clinical and pathological characteristics of COVID-19 differ significantly from those of SARS. How and whether SARS-CoV-2 evades (cellular) immune surveillance requires further elucidation. In this study, we show that SARS-CoV-2 infection leads to major hi...
Abstract The spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and ongoing coronavirus disease 2019 (COVID-19) pandemic underscores the need for new treatments. Here, we report that cannabidiol (CBD) inhibits infection of SARS-CoV-2 in cells and mice. CBD and its metabolite 7-OH-CBD, but not THC or other congeneric cannabinoids tested, potently block SARS-CoV-2 replication in lung epithelial cells. CBD acts after viral entry, inhibiting viral gene expression a...
Abstract TANK-binding kinase 1 (TBK1) is a key signalling component in the production of type-I interferons, which have essential antiviral activities, including against SARS-CoV-2. TBK1, and its homologue IκB kinase-ε (IKKε), can also induce pro-inflammatory responses that contribute to pathogen clearance. While initially protective, sustained engagement of type-I interferons is associated with damaging hyper-inflammation found in severe COVID-19 patients. T...
Abstract During respiration, humans breathe in more than 10,000 liters of...COVID-19 paralyzes macrophages through the type II interferon signaling pathway, paving the way for potentially deadly secondary bacterial infections.Further more, Bio X Cell’s anti-Mouse LFA-1α antibody (Clone M17/4), was used to demonstrate that LFA-1 is necessary for AMs to crawl on the s...
Abstract The causative agent of the COVID-19 pandemic, SARS-CoV-2, is steadily mutating during continuous transmission among humans. Such mutations can occur in the spike (S) protein that binds to the ACE2 receptor and is cleaved by TMPRSS2. However, whether S mutations affect SARS-CoV-2 cell entry remains unknown. Here, we show that naturally occurring S mutations can reduce or enhance cell entry via ACE2 and TMPRSS2. A SARS-CoV-2 S-pseudotyped lentivirus exhibits substantially low...
Abstract Efficient immune responses against viral infection are determined by sufficient...COVID-19) spike antibody [1A9] (GTX632604) are featured in this study.
Abstract In-depth analysis of SARS-CoV-2 quasispecies is pivotal for a thorough understating of its evolution during infection. The recent deployment of COVID-19 vaccines, which elicit pro- tective anti-spike neutralizing antibodies, has stressed the importance of uncovering and characterizing SARS-CoV-2 variants with mutated spike proteins. Sequ...
Our COVID-19 / SARS-CoV-2 Portfolio for Research and Diagnostics:
Due to the great demand, we took the PrimerDesign and Clonit quantitative real-time PCR kits (CE IVD) for diagnostic SARS-CoV-2 detection in stock for you at BIOZOL. These products are ready for shipment from Eching. Clonit quanty COVID-19 new coron...
COVID-19 Rapid Tests wanted! But which ones?! Our selection guide helps you through the jungle of different test formats, regulations, and requirements. All our COVID-19 (SARS-CoV-2) Rapid tests are so called lateral flow immunochromatographic assays (same principle as a common pregnancy test) with an internal procedural control, and they all give you a qualitative result within 15 minutes. They differ in applicati...
Supporting real-time PCR, which is the gold standard in the diagnosis of the novel SARS-CoV-2 virus, and our chromatographic tests, the ELISA technique can make a valuable contribution to COVID-19 research and diagnostics. ELISA kits are available from BIOZOL for the detection of both SARS-CoV-2 peptides and specific COVID-19 antibodies. Diagnostic ELISA Kits (CE IVD)...
GeneTex supports science with one of the most comprehensive portfolios...COVID-News/GeneTex_SARS-CoV-2-spike-and-Nucleocapsid-protein_1280_20201016-u.jpg" style="height:375px; width:800px" /> GeneTex’s antibodies against the spike protein of SARS-CoV-2 exhibit high sensitivity and specificity. Antibodies against both the S1 and S2 subunits, as well as the S1 receptor-bind...
Which mutations in SARS-CoV-2 coronavirus cause the higher transmissibility of...COVID-News/Sars-CoV-2_Structure-EN.jpg" style="float:right; height:149px; margin:5px; width:250px" />Sequence and structure of the COVID-19 pathogen SARS-CoV-2 are well studied and described. Of particular interest with respect to diagnostics and drug development is the spike protein (S-protein) due to its role in the interaction with human host receptors. Since the beginning of the circulation of SARS-CoV-2...
Sequence and structure of the coronavirus SARS-CoV-2 are well understood and appropriate targets for vaccines and therapeutics have been defined. Specific recombinant antibodies against these target proteins are an important tool for further research into the mode of action of the virus and the diverse clinical picture of COVID-19 as well as for drug and diagnostica development. With the help of our partners, we are able to offer you a wide range of specific antibodies and antibody fragments...
Basis of successfull vaccinations against pathogens as the Coronavirus SARS-CoV-2 is the type, and efficiency of the induced immune response. The human adaptive immune system relies on both, the (antibody-mediated) humoral as well as the T-cell mediated immunity. Antibodies of diverse isotype and against different SARS-CoV-2 antigens are produced and can be detected and separately id...
In a recently published announcement, Biontech expresses their gratitude to their employees and various partners, who have assisted the company in successfully developing a vaccine for COVID-19. The BioNTech-Pfizer vaccine has been shown to be 95% effective in preventing COVID-19 and has received emergency use authorizations from mo...
Basis of successfull vaccinations against pathogens as the Coronavirus SARS-CoV-2 is the type, and efficiency of the induced immune response. The human adaptive immune system relies on both, the humoral immunity as well as the T-cell mediated immunity. Our tools for flow cytometrical analysis of B- and T-cell subsets allow to study the underlying processes of the vaccine or infection induced immunity. ...
The severity of COVID-19 disease, according to current knowledge, is more strongly determined by an overreaction of the coagulation and immune system than by the virus itself. Patients with severe COVID-19 infection may develop a cytokine release syndrome (CRS), also known as hyperinflammation or cytokine storm, which is characterized by a significant increase in pro-inflammatory cytokines such as IL-6, IL-1ß, IL-2R, IL-8, TNF-α. CRS is one of the most common comp...
Sequence and structure of the new coronavirus SARS-CoV-2 have been...COVID-News/Sars-CoV-2_Structure-EN.jpg" style="height:297px; width:500px" /> At BIOZOL you can obtain recombinant S-proteins in different variants, N-proteins, and the main protease (Mpro) from different expression systems, as well as suitable substrates, antibodies and assays. Furthermore, we can offer you a range of ...
COVID Antigen Self Tests are designed to be selfapplied by the test subject. The sample is taken from the lower part of the nose with help of a (included) nasal swab. The sensitivity (reliability of the result) of correctly applied self tests corresponds to that of the professional antigen tests. We sell our self-tests either as five individually packaged tests or in pa...
Our Partner GeneTex offers an extensive line of research antibodies and proteins to support the study of SARS-CoV-2 The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), previously known as 2019 Novel Coronavirus (2019-nCoV), is a positive-sense, single-stranded RNA virus that causes the potentially lethal COVID-19 respiratory tract infection. This new virus belongs to the genus Betacoronavirus, which also includes SARS-CoV and MERS-CoV. The first case of COVID-19 was de...
COVID Antigen Rapid Tests for professional use are diagnostic devices (CE-IVD marked). They must be applied by a trained person, which may be a doctor or pharmacist, but as well a designated staff in your company or institution, who attended a special training.* Professional Rapid Tests come as cost-efficient kits of 20 or 25 test cassettes. All needed equipment (like buffer and swabs) is included, but is not single packed. These kits a...
For a report in the Business Insider magazine about the potential of the new COVID-19 antigen rapid tests, our managing director Jonas Bäuerle gave an interview with the business reporter Franziska Telser. Under the title A piece back to the former normality? Why Corona rapid tests can be groundbreaking - and what you need to know about them the business insider discusses differences between different test methods, as well as the advantages and disadvantages...
Functional screening of peptides for MHC class I binding is...COVID-19 virus proteins in the most common alleles: HLA-A2, A11, A24, A3 and HLA-DR1, DR4, DR15. MBLI has researched and tested SARS-CoV-2 peptide sequences of interest to assess peptide-MHC binding using QuickSwitch™ kits. These peptides are bundled with their respective QuickSwitch ™ allele. By purchasing a bundle, you can create up to 8 custom tetramers in 1 day- saving you significant time and...
Webinar: Simulating COVID-19 peptide presentation using the QuickSwitch™ MHC Platform Presented by MBL Int. Date: Tuesday, 13th July, at 06:00 pm (CEST)
Viral epidemics are one of the greatest challenges of our...covid-antikoerper">SARS-CoV-2 Antibodies Related Topics: >> dsRNA detection with antibody clone J2 >> SARS-CoV-2 (COVID-19) research and diagnostics
At BIOZOL you get everything you need for flow cytometry...covid-t-cells">>> Scientific News: COVID-19 immunity - Cytometric lymphocyte detection >> Scientific News: Examination of phagocytic activity by flow cytometry >> BIOZOL Brochure Flow Cytometry
We...COVID-19. Studies are still lacking to understand which combination therapy approaches will have the greatest potency and synergy against SARS-CoV-2 Omicron sub-variants. Dr. Jean will present the recent discovery of novel pan-coronavirus antiviral drug...
The antiviral activity of lectins is largely attributed to direct...COVID-19. Our partner Vector Laboratories is an established manufacturer of many plant lectins that are described in the literature as valuable tools in ongoing research to elucidate their potential in suppression of viral activity. Below is a list of mannose-specific and mannose/glucose-specific lectins, available in unconjugated and conjugated formats. ...
In our Scientific Content Area, we collect interesting webinar recordings, online courses and videos from our manufacturers on a variety of topics, including standard methods such as PCR or ELISA, current hot topics such as CRISPR/Cas9 and COVID-19, but also more specific technical questions. What they all have in common is that they all deal with very specific applications, demonstrated and explained by specialists in their field. Newest videos added include tips for succesful immu...
Cytokines are a class of proteins produced by...COVID-19: Cytokines and cytokine detection >> Specialized media, supplements and growth factors for cell culture